Monday, 4 March 2013

#chemclub Roundup: week 2

It's been a productive week for #chemclub, with 20 papers posted for discussion. Here are some highlights - leave a comment and let us know what you thought.

If you're not sure what #chemclub is, have a look here.

First up, Funel and Abele review the use of the Diels-Alder reaction on industrial scale. Derek Lowe highlighted this earlier in the week, describing it as "pretty much all you need to know about the reaction's industrial side".

From @V_Saggiomo we have a paper on the synthesis of polymer particules with well-defined and unusual shapes. It's nicely-written, thorough, and seems (relatively!) simple to implement. On top of that, they one-upped #BlogSyn by reporting their SI as a video, a nice touch.

Speaking of which, we're assured that this method requires no mojo: the use of KI to activate acyl chlorides to reaction with relatively weak nucleophiles such as sulfonamides and hindered (2,6-tBu) phenols.
Once again, @Total_Synthesis posted several recent papers. I quite liked the concise synthesis of (+)-obolactone reported by Walleser and Brückner; it nicely exploits the symmetry of the molecule during the first half of the synthesis. I wonder if @robstockman approves?
A bit of chemical biology from @NeilWithers: genetically modifying E. coli to express fluorinated tyrosine residues, which can be used to directly study the effects of post-translational phosphorylation of these residues. 
Finally, my own contribution is a recent Hoveyda paper in Nature. @AzaPrins summed it up nicely: "just nice, solid methodology, can be useful to many projects out there! And the word 'cheap' is always going to appeal to me!"
Leave your comments, criticisms, rantings and ravings below, and post your Monday morning reading to #chemclub.

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