If you're not sure what #chemclub is, have a look here.
First up, Funel and Abele review the use of the Diels-Alder reaction on industrial scale. Derek Lowe highlighted this earlier in the week, describing it as "pretty much all you need to know about the reaction's industrial side".
Interesting article on the industrial Diels-Alder. #chemclub onlinelibrary.wiley.com/resolve/doi?DO…
— Chemist In Japan (@chemistinjapan) February 27, 2013
Industrial Applications of the Diels–Alder Reaction bit.ly/XCxXpM #chemclub
— Arash Soheili (@tonyarash) February 27, 2013
From @V_Saggiomo we have a paper on the synthesis of polymer particules with well-defined and unusual shapes. It's nicely-written, thorough, and seems (relatively!) simple to implement. On top of that, they one-upped #BlogSyn by reporting their SI as a video, a nice touch.
this is so great.The whole paper/methods explained in the Supportin Information 7min video. onlinelibrary.wiley.com/doi/10.1002/pp… cc @sebspain #chemclub
— Vittorio Saggiomo (@V_Saggiomo) February 27, 2013
Speaking of which, we're assured that this method requires no mojo: the use of KI to activate acyl chlorides to reaction with relatively weak nucleophiles such as sulfonamides and hindered (2,6-tBu) phenols.
RT @azaprins Love Finkelstein? You'll like this cool way of using KI.pubs.acs.org/doi/abs/10.102… … Used this last week, worked well.#chemclubOnce again, @Total_Synthesis posted several recent papers. I quite liked the concise synthesis of (+)-obolactone reported by Walleser and Brückner; it nicely exploits the symmetry of the molecule during the first half of the synthesis. I wonder if @robstockman approves?
— Andrew (@_byronmiller) March 3, 2013
Enantioselective Synthesis of (+)-Obolactone in Org. Lett. by Reinhard Brückner bit.ly/13wqpJa #totalsynthesisA bit of chemical biology from @NeilWithers: genetically modifying E. coli to express fluorinated tyrosine residues, which can be used to directly study the effects of post-translational phosphorylation of these residues.
— Total Synthesis (@Total_Synthesis) March 2, 2013
Genetically encoding unnatural amino acid 19F NMR probes into proteins: trunc.it/mdntk Nice #chemclubFinally, my own contribution is a recent Hoveyda paper in Nature. @AzaPrins summed it up nicely: "just nice, solid methodology, can be useful to many projects out there! And the word 'cheap' is always going to appeal to me!"
— Neil Withers (@NeilWithers) March 1, 2013
Slick Hoveyda paper on organocatalysis. I wonder how many years of work this represents. nature.com/nature/journal… #chemclubLeave your comments, criticisms, rantings and ravings below, and post your Monday morning reading to #chemclub.
— Andrew (@_byronmiller) February 27, 2013