Tuesday, 19 March 2013

#chemclub Roundup: week 4

Some highlights from #chemclub Twitter feed this week. Featuring aryl fluorides, self-replication, and a bit of blogroll. Not sure what #chemclub is? Have a gander here.

First up, a paper from last year which I found very interesting - the use of DNA crystal growth to replicate genetic information. It uses a very different mechanism of self-replication to most examples in the literature, but propagates genetic information with impressive fidelity for an enzyme-free system.
@JessTheChemist shared a Hartwig paper on the conversion of readily-available aryl boronates to aryl fluorides. It's limited by significant formation of the proto-deborylated byproduct, but is pretty mild and has good substrate scope.
@clay_owens pointed out that Melanie Sanford published a very similar paper barely a month later.
@tonyarash shares a metal-free synthesis of nicely functionalised biaryls using Grignard chemistry. Seems like a pretty straightforward method and it's a nicely-written paper.
For the amateur historians, @nathanbroon shares a 1943 paper looking at knowledge of chemistry - mainly metallurgy and dyes - in the Old Testament. It's a little dry but well worth reading; there was quite a lot of empirical knowledge, but very little theory from the looks of it.
Finally, a few interesting blog posts. The brilliant Henry Rzepa asks if n-BuLi is aromatic; the Curious Wavefunction makes the case for origins research; and the Baran group talk advanced chromatography.

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